王帅;陈蕾;张宁;王亚文;贾萍;

• 1:南阳市第二人民医院药学部
• 2:南阳市第二人民医院产科
• 3:南阳市第二人民医院检验科

摘要(Abstract)：

目的 分析成纤维细胞生长因子-23(FGF-23)基因多态性与乙肝病毒(HBV)感染孕妇应用富马酸丙酚替诺福韦(TAF)阻断效果的相关性，提高HBV感染孕妇治疗效果。方法 选取2017年5月-2020年5月南阳市第二人民医院收治的96例HBV感染孕妇作为研究对象，按照TAF母婴传播免疫阻断结果将孕妇分为阻断成功组64例与阻断失败组32例，采用限制性片段长度多态性聚合酶链反应(PCR-RFLP)检测FGF-23基因多态性，采用Logistic回归分析FGF-23基因多态性与HBV感染孕妇TAF阻断效果的关系。结果 阻断成功组FGF-23基因rs7955866位点GG基因频率及G等位基因频率和rs3812822位点TT基因频率及T等位基因频率均高于阻断失败组(P<0.05),两组rs13312756位点基因频率及等位基因频率比较差异无统计学意义。Logistic回归分析显示，FGF-23基因rs7955866位点AA基因型和rs3812822位点CC基因型可能增加HBV感染孕妇TAF阻断失败风险(P<0.05)。结论 FGF-23基因rs7955866位点AA基因型和rs3812822位点CC基因型与HBV感染孕妇TAF阻断效果有关。

关键词(KeyWords)： 乙肝病毒感染;孕妇;富马酸丙酚替诺福韦阻断;成纤维细胞生长因子-23基因多态性

Abstract:

Keywords:

基金项目(Foundation): 河南省医学科技攻关计划项目(2018020985);; 南阳市软科学研究计划项目(RKX062)

作者(Authors): 王帅;陈蕾;张宁;王亚文;贾萍;

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