赖小玲;王晓秋;麦金丽;姚柳芳;洪嘉恩;黄惠兴;

• 1:南方医科大学附属东莞医院肿瘤内科
• 2:南方医科大学附属东莞医院放疗科

摘要(Abstract)：

目的 探讨脓肿型肉芽肿性乳腺炎(GM)病原学特点及Nod样受体家族含有pyrin结构域蛋白3(NLRP3)炎症小体和白细胞介素(IL)-1β表达变化。方法 选取2016年6月-2021年6月南方医科大学附属东莞医院收治的84例GM患者为研究对象，记录脓肿型GM占比及感染病原学特点，检测GM患者外周血C-反应蛋白(CRP)水平、IL-2、IL-8和IL-6水平及乳腺病变组织NLRP3、凋亡相关斑点样蛋白(ASC)、半胱氨酸蛋白酶1(caspase-1)和IL-1β水平，分析其临床意义。结果 38例(45.24%)脓肿型GM患者共分离病原菌32株，主要为棒状杆菌，其中水生棒状杆菌9株、微小棒状杆菌8株、G群棒状杆菌5株、杰氏棒状杆菌4株；29株棒状杆菌对克林霉素耐药率较高，对庆大霉素、利奈唑胺、万古霉素均敏感。与非脓肿组相比，脓肿组外周血CRP、红细胞沉降率(ESR)、催乳素(PRL)、IL-2、IL-8、IL-6水平及乳腺组织NLRP3、ASC、caspase-1和IL-1β水平均升高(P<0.05); NLRP3、ASC、caspase-1、IL-1β及其联合鉴别诊断脓肿型GM的曲线下面积分别为0.795、0.799、0.754、0.757和0.932。结论 脓肿型GM病原菌以棒状杆菌为主，对庆大霉素、利奈唑胺、万古霉素均敏感，NLRP3炎症小体和IL-1β表达增强，且对脓肿型GM有良好的鉴别效能。

关键词(KeyWords)： 肉芽肿性乳腺炎;脓肿;病原菌;NLRP3炎症小体;白细胞介素-1β;鉴别诊断

Abstract:

Keywords:

基金项目(Foundation): 广东省医学科研基金项目(A2020076)

作者(Authors): 赖小玲;王晓秋;麦金丽;姚柳芳;洪嘉恩;黄惠兴;

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